Opposition supporters marched toward the presidential office in the city center from different directions in the morning. Some protesters seized quite a few police vehicles and drove them toward the presidential office.

The protesters were attempting to storm into the building, and were demanding negotiations with President Bakiyev and Prime Minister Usenov. They threatened to occupy the presidential office if their demands were not met.

In a related development, the regional government buildings in Naryn and Chui states were overrun by opposition protesters earlier Wednesday, witnesses told Xinhua.

About 3,000 opposition protestors gathered at a central square in the provincial capital of Naryn.

The U.S. embassy in Bishkek Wednesday urged the Kyrgyz government and opposition protesters to start negotiations as early as possible.

The U.S. embassy said in a statement that the U.S. government was deeply concerned about the latest unrest in some Kyrgyz cities.

The statement hoped that all the parties concerned in Kyrgyzstan would abide by law, begin talks as soon as possible, and solve their rifts within the framework of law.

Earlier, Russia had urged restraint between Kyrgyz authorities and the opposition and called on them to resolve their disputes through democratic means instead of violence.

In a Tuesday unrest in the northern Kyrgyz town of Talas, at least 15 police officers were missing, and 16 civilians and 85 policemen were injured, Prime Minister Usenov said.

The unrest broke out after head and deputy head of the main opposition Ata-Meken party were arrested Tuesday. Kyrgyz authorities said the unrest had been put under control.