Top-ranked Roger Federer suffered a fourth round defeat at the ATP and WTA Masters tennis tournament in Miami on Tuesday.

The Swiss lost to 16th-seeded Tomas Berdych 6-4, 6-7 (3) and 7-6 (6) in two hours and 51 minutes, just his second loss to the Czech in their 10 career meetings.

Federer, who has 16 Grand Slam titles, was also knocked out in the third round of his last tournament two weeks ago at Indian Wells and had to withdraw from the Dubai event last month with a lung infection.

Berdych reached his fifth quarter-final of the season and has a 15-7 record this season. He lost to Nadal in the quarters at Indian Wells and made the semis at Brisbane before being eliminated by Roddick.

In other matches, six-time Grand Slam champion Rafael Nadal and American Andy Roddick remained as the two of the top eight seeds advancing to the quarterfinals.

Nadal outlasted fellow Spaniard David Ferrer 7-6 (5), 6-4, and will next face eighth seed Frenchman Jo-Wilfried Tsonga who beat No. 12 Juan Carlos Ferrero 6-2, 6-2.

Former champion Roddick beat the unseeded German Benjamin Becker 7-6 (4), 6-3, improving to 23-4 this year and advancing to his seventh quarterfinal in 11 previous appearances in the event.

Also, in the men's fourth round, American Mardy Fish retired with a back injury, trailing Mikhail Youzhny 6-1, 1-0. Robin Soderling reached the quarterfinals for the first time with a 6-0, 6-7 (3), 6-2 win over Chilean Fernando Gonzalez, and Nicolas Almagro eliminated Thomaz Bellucci 6-4, 3-6, 7-6 (3).

In women's play, Venus Williams beat Agnieszka Radwanska 6-3, 6-1 to advance to the semis.