Jennifer Aniston is to guest star on her former "Friends" star Courteney Cox's current television comedy series, "Cougar Town," the ABC TV network said on Monday.

Aniston will appear in the show's second-season premiere airing September 22 on U.S. network. The actress will play a therapist giving advice to Cox's character -- a divorced 40something woman who is getting back into a dating scene filled with younger men.

It is the not first time Aniston has teamed with Cox, who is also her real-life best friend, after "Friends" ended in 2004. She also appeared on Cox's previous TV series, "Dirt," in 2007.

"Cougar Town" executive producer Bill Lawrence told Entertainment Weekly, Cox wanted her to establish the show first before calling on Aniston.

"Once we did and once it was clicking, I think that not only did Courteney feel comfortable talking to Jen about doing it, but comfortable in how funny she thinks the show is and that Jen would like it and fit into this world really well," said Lawrence.

Shooting on the episode will begin next week. Industry sources said the TV show happens to be shooting near the set of Aniston's latest movie "Horrible Bosses" making it convenient for Aniston to coordinate her schedule.

Lawrence told Entertainment Weekly that they are "intentionally implying that it's a therapist Courteney has been using for a while" leaving the door open for Aniston to return if all goes well.

Aniston is not the first "Friends" star Cox has called on to guest star on "Cougar Town." Last season, Lisa Kudrow played a dermatologist whose services Cox's character sought out.