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The International Retina Summit 100 (IRS100) · 2025 was held in Changsha, Hunan, from Nov. 21 to 23. As a major event in the global ophthalmology field, the forum focused on key frontiers in retinal medicine, including gene therapy, AI-assisted diagnosis, and surgical robotics. It brought together more than 100 leading experts and scholars from China and abroad, providing a high-level platform for sharing advances and building global consensus in retinal research and clinical practice.