Bruno Fernandes saw a second-half penalty saved as Manchester United lost 3-1 to Brentford, extending Ruben Amorim's troubled reign.

Manchester United's defensive frailties were exposed early when Igor Thiago pounced on chaos at the back to hand the host a two-goal advantage within 20 minutes.

Benjamin Sesko halved the deficit with his first strike in the 26th minute since his 74-million-pound switch from RB Leipzig, offering a lifeline. That chance to level came when Brentford skipper Nathan Collins dragged back Bryan Mbeumo in the box. After a lengthy delay for a VAR red card review and two home substitutions, Fernandes stepped up, only to see his effort pushed away by Caoimhin Kelleher in the 76th minute.

Brentford sealed the win in stoppage time as Mathias Jensen lashed a powerful effort past Altay Bayindir.

The result means United is still without back-to-back league victories under Amorim, who nears a year in charge with just 34 points from 33 Premier League matches.